###Jingren Zhang\n\n\n__Jing-Ren Zhang, Ph.D.__\n\nProfessor, Center for Infectious Disease Research, Tsinghua University School of Medicine\n\n__Tel__: +86-10-62795892\n\n__E-mail__: zhanglab at tsinghua.edu.cn\n\n####Personal profile:\nDr. Zhang received his PhD degree in Microbiology and Molecular Genetics in the University of Texas-Medical School in Houston in 1997. After a postdoctoral work in St. Jude Children’s Research Hospital, he held a faculty position in the Center for Immunology and Microbial Disease at Albany Medical College from November of 2000 to June of 2009. Dr. Zhang joined Tsinghua University School of Medicine as a full professor and assistant dean in July of 2010. He has published many research articles in prestigious international journals, and was listed as the most cited Chinese researchers in the areas of microbiology and immunology in 2014 and 2015.\n\n####Research interest:\nThe Zhang laboratory studies the molecular mechanisms behind bacterial pathogenesis and drug resistance. The major focus is on the pathogens that cause respiratory infections, such as Streptococcus pneumoniae, Francisella tularensis, and Mycobacterium tuberculosis. The main research questions include:\nHow bacterial pathogens survive and grow in different host niches;\nHow host diseases are generated;\nHow the understanding of basic bacterial biology can be used to improve the control of bacterial diseases.\n\n####Recent publications:\n1. Wen, Z., Y. Liu, F. Qu, and J.R. Zhang*. 2016. Allelic variation of the capsule promoter diversifies encapsulation and virulence in Streptococcus pneumoniae. Scientific Reports 6:30176. DOI: 10.1038/srep30176.\n2. Li, J. J.-W. Li, Z. Feng, J. Wang, H. An, Y. Liu, Y. Wang, K. Wang, X. Zhang, Z. Miao, W. Liang, R. Sebra, G. Wang, W.-C. Wang, and J.-R. Zhang*. 2016. Epigenetic switch driven by DNA inversions dictates phase variation in Streptococcus pneumoniae. PLOS Pathogens 12(7): e1005762. doi:10.1371/journal.ppat.1005762. Highlighted in Nature Review Microbiology (doi: 10.1038/nrmicro.2016.122).\n3. Li, G., Z. Liang, X. Wang, Y. Yang, J. Shao, M. Li, Y. Ma, F. Qu, D. A. Morrison, and J.-R. Zhang*. 2016. Addiction of hyper-transformable pneumococcal isolates to natural transformation for in vivo fitness and virulence. Infection and Immunity 84:1887-1901. doi:10.1128/IAI.00097-16.\n4. He, L., M. K. Mohan Nair, Y. Chen, X. Liu, M. Zhang, K. R. O. Hazlett, H. Deng*, and J.-R. Zhang*. 2016. The protease locus of Francisella tularensis LVS is required for stress tolerance and infection of mammalian host. Infection and Immunity 84:1387-402. doi:10.1128/IAI.00076-16.\n5. Bai, X.-H., Q. Li, Y.-L. Jiang, J.-R. Zhang*, Y. Chen*, and C.-Z. Zhou*. 2016. Structural comparison and simulation of pneumococcal peptidoglycan hydrolase LytB. Methods in Molecular Biology. 1440:271-83. doi:10.1007/978-1-4939-3676-2_19.\n6. Yang, H., X. Liu, Q. Li, L. Li, J.-R. Zhang*, and Y. Tang*. 2016. Total synthesis and preliminary SAR study of (+/-)-merochlorins A and B. Org Biomol Chem. 14:198-205.\n7. Yang, T., G. Chen, Z. Sang, Y. Liu, X. Yang, Y. Chang, H. Long, W. Ang, J. Tang, Z. Wang*, G. Li, S. Yang, J.-R. Zhang, Y. Wei, and Y. Luo*. 2015. Discovery of a teraryl oxazolidinone compound (S)-N-((3-(3-fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)phenyl)-2-oxooxazolidin-5 -yl)methyl)acetamide phosphate as a novel antimicrobial agent with enhanced safety profile and efficacies. Journal of Medical Chemistry 58:6389-409.\n8. Wang, L., Y.-L. Jiang, J.-R. Zhang, C.-Z. Zhou, and Y. Chen*. 2015. Structural and enzymatic characterization of the choline kinase LicA from Streptococcus pneumoniae. PLoS One 10:e0120467.\n9. Wen, Z., O. Sertil, Y. Chen, S. Zhang, X. Liu, W.-C. Wang, and J.-R. Zhang*. 2015. The sequence elements upstream of the core promoter are necessary for the full transcription of the capsule gene operon in Streptococcus pneumoniae strain D39. Infection and Immunity 83:1957-1972.\n10. Achila, D., A. Liu, R. Banerjee, Y. Li, E. Martinez-Hackert, J.-R. Zhang*, and H. Yan*. 2015. Structural Determinants of Host Specificity of Complement Factor H Recruitment by Streptococcus pneumoniae. Biochemical Journal 465:325-335. OI: 10.1042/BJ20141069.\n11. Feng, Z., J. Li , J.-R. Zhang*, and X. Zhang*. 2014. qDNAmod: a statistical model based tool to reveal intercellular heterogeneity of DNA modification from SMRT sequencing data. Nucleic Acids Research 42:13488–13499.\n12. Zhu, D., L. Wang, G. Shang, X. Liu, J. Zhu, D. Lu, L. Wang, B. Kan, J.-R. Zhang, and Y. Xiang. 2014. Structural biochemistry of a Vibrio cholerae dinucleotide cyclase reveals cyclase activity regulation by folates. Molecular Cell 55:931-937.\n13. Zeng X.-F., Y. Ma, L. Yang, L. Zhou, Y. Xin, L. Chang, J.-R. Zhang, and X. Hao*. 2014. A C-terminal truncated mutation of licC attenuates the virulence of Streptococcus pneumoniae. Research in Microbiololgy 165: 630-638.\n14. Song, Y., Q. Li, X. Liu, Y. Chen, Y. Zhang, A. Sun, W. Zhang, J.-R. Zhang, and J. Ju*. 2014. Cyclic hexapeptides from the deep South China Sea-derived Streptomyces scopuliridis SCSIO ZJ46 active against pathogenic Gram-positive bacteria. Journal of Natural Products 77:1937-1941.\n15.Bai, X.-H. , H.-J. Chen, Y.-L. Jiang, Z. Wen, Y. Huang, W. Cheng, Q. Li, L. Qi, J.-R. Zhang*, Y. Chen*, and C.-Z. Zhou*. 2014. Structure of pneumococcal peptidoglycan hydrolase LytB reveals insights into the bacterial cell wall remodeling and pathogenesis. Journal of Biological Chemistry 289:23403–23416. doi: 10.1074/jbc.M114.579714.\n16. Yang, Y.-H., Y.-L. Jiang, J. Zhang , L. Wang, X.-H. Bai, S.J. Zhang, Y.-M. Ren, N. Li, Y.-H. Zhang, Z. Zhang, Q. Gong, Y. Mei, T. Xue, J.-R. Zhang, Y. Chen*, and C.-Z. Zhou*. 2014. Structural insights into SraP-mediated Staphylococcus aureus adhesion to host cells. PLOS Pathogens 10:e1004169. doi: 10.1371/journal.ppat.1004169.\n17. Pan, X., Y. Yang, and J.-R. Zhang*. 2014. Molecular basis of host specificity in human pathogenic bacteria. Emerging Microbes and Infections 3:e23.\n18. Gupta, R., J. Yang, Y. Dong, E. Swiatlo, J.-R. Zhang, D.W. Metzger, and G. Bai*. 2013. Deletion of arcD in Streptococcus pneumoniae D39 impairs its capsule and attenuates virulence. Infection and Immunity 81:3903-3911.\n19. Qaidi, S. E., J. Yang, J.-R. Zhang, D. W. Metzger, and G. Bai*. 2013. The vitamin B6 biosynthesis pathway in Streptococcus pneumoniae is controlled by pyridoxal 5’-phosphate and the transcription factor PdxR, and impacts on ear infection. Journal of Bacteriology 195:2187-2196.\n20. Li, G., F. Z. Hu, X. Yang, Y. Cui, J. Yang, F. Qu, G. F. Gao, and J.-R. Zhang*. 2012. The complete genome sequence of Streptococcus pneumoniae strain ST556, a multi-drug resistant isolate from an otitis media patient. Journal of Bacteriology 194:3294-3295.\n21. Han, H., C. Liu , Q. Wang, C. Xuan, B. Zheng, J. Tang, J. Yan, J.-R. Zhang, M. Li, H. Cheng, G. Lu, G.F. Gao*. 2012. The two-component system Ihk/Irr contributes to the virulence of Streptococcus suis serotype 2 strain 05ZYH33 through alteration of the bacterial cell metabolism. Microbiology 158:1852-1866.\n22. Su, J., J. Asare, J. Yang, M. Kumar, J. Mazurkiewicz, Y. Abu-Kwaik, and J.-R. Zhang*. 2011. The capBCA locus is required for intracellular growth of Francisella tularensis. Frontiers in Cellular and Infection Microbiology 2:83.\n23. Zhang, Q., F. Gao, H. Peng, H. Cheng, Y. Liu, J. Tang, J. Thompson, G. Wei, J.-R. Zhang, Y. Du, J. Yan, and G.F. Gao*. 2009. Crystal structures of Streptococcus suis mannonate dehydratase (ManD) and its complex with substrate: genetic and biochemical evidence for a catalytic mechanism. Journal of Bacteriology 191:5832–5837.\n24. Chen, H., Y. Ma, J. Yang, C. O'Brien, S. L. Lee, J. E. Mazurkiewicz, S. Haataja, J.H. Yan, G.F. Gao, and J.-R. Zhang*. 2008. Genetic requirement for pneumococcal ear infection. PLoS One 3:e2950.\n25. Lu, L., Z. Ma, T. S. Jokiranta, A. R. Whitney, F. R. DeLeo, and J.-R. Zhang*. 2008. Species-specific interaction of Streptococcus pneumoniae with human complement factor H. Journal of Immunology 181:7138-7146.\n26. Ma, Z., and J.-R. Zhang*. 2007. RR06 activates the transcription of spr1996 and cbpA in Streptococcus pneumoniae. Journal of Bacteriology 189:2497-2509.\n27. Su, J., J. Yang, D. Zhao, T. H. Kawula, J. A. Banas, and J.-R. Zhang*. 2007. Genome-wide identification of Francisella tularensis virulence determinants. Infection and Immunity 75:3089-3101.\n28. Lu, L., Y. Ma, and J.-R. Zhang*. 2006. Streptococcus pneumoniae recruits complement factor H through the amino terminus of CbpA. Journal of Biological Chemistry 278:48178-48187.\n29. Lu, L., M. E. Lamm, H. Li, B. Corthesy, and J.-R. Zhang*. 2003. The human polymeric immunoglobulin receptor binds to Streptococcus pneumoniae via domains 3 and 4. Journal of Biological Chemistry 278:48178-48187.\n30. Zhang, J.-R., K. Mostov, M. Lamm, M. Nanno, S. Shimida, M. Ohwaki, and E. Tuomanen*. 2000. The polymeric immunoglobulin receptor translocates pneumococci across human nasopharyngeal epithelial cells. Cell 102:827-837.\n31. Zhang, J.-R., I. Idanpaan-Heikkila, W. Fischer, and E. Tuomanen*. 1999. Pneumococcal licD2 gene is involved in phosphorylcholine metabolism. Molecular Microbiology 31:1477-1488.\n32. Zhang, J.-R. and E. Tuomanen*. 1999. Molecular and cellular mechanisms for microbial entry into the CNS. Journal of NeuroVirology 5:591-603.\n33. Zhang, J.-R. and S. J. Norris*. 1998. Kinetics and in vivo induction of genetic variation of vlsE in Borrelia burgdorferi. Infection and Immunity 66:3689-3697.\n34. Zhang, J.-R. and S. J. Norris*. 1998. Genetic variation of the Borrelia burgdorferi gene vlsE involves cassette-specific, segmental gene conversion. Infection and Immunity 66:3698-3704.\n35. Zhang, J.-R., J. M. Hardham, A. G. Barbour, and S. J. Norris*. 1997. Antigenic variation in Lyme disease borrelia by promiscuous recombination of vmp-like sequence cassettes. Cell 89:275-285.\n36. Dabbert, C. D., R. L. Lockmiller*, J.-R. Zhang, C. W. Qualls, and K. Burnham. 1994. High in vitro endotoxin responsiveness of macrophage from an endotoxin-resistant wild rodent species, Sigmodon hispidus. Developmental and Comparative Immunology 18:147-153\n\n####Book Chapter\n1. J.-R. Zhang*, M. G. Marinus, and H. Deng. 2015. Methylation and other modifications of nucleic acids and proteins. In Reference Module in Biomedical Sciences (Michael Caplan ed.), chapter 2448 (book chapter). Elsevier, Amsterdam.\n2. Wen, Z. and J.-R. Zhang*. 2015. Bacterial capsules, p. 33-52 (book chapter). In Molecular Medical Microbiology (Y.-W. Tang, M. Sussman, D. Liu, I. Poxton, and J. Schwartzman ed.). Academic Press, Amsterdam.\n\n\n\n\n